HCID 23461740, compound → HCID 13725072, compound

HRID 2286518Notes

Reaction equation

HRID 2286518 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[NH:16][CH:17]=[CH:18][CH:19]=1)C1C=CC=CC=1>[Pd].CO>[OH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[NH:16][CH:17]=[CH:18][CH:19]=1

Participants

4

Reactant 1

HCID 23461740HCID 23461740, compound

Product 1

HCID 13725072HCID 13725072, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

150 mg of 10% strength palladium-on-charcoal catalyst are added to 1.5 g (6 millimoles) of 2-(o-benzyloxyphenyl)-pyrrole in 30 ml of methanol and hydrogenation is carried out under slightly superatmospheric pressure. The residue which remains after separating off the catalyst and evaporating the solution is recrystallized from a mixture of toluene and petroleum ether (boiling range 40°-60° C.). The yield of 0.8 g corresponds to 84% of theory; melting point 100°-101° C.

Workup

  1. customafter separating off the catalyst
  2. customevaporating the solution
  3. customis recrystallized from a mixture of toluene and petroleum ether (boiling range 40°-60° C.)

Sources & evidence

ORD record
ord-183ffbe39f8a41dc9caaf9e2b92242e4
Source dataset
uspto-grants-1981_05
Patent number
US04267187

Reaction notes

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