Potassium Carbonate → 2-{2-[(Oxiran-2-yl)methoxy]phenyl}-1H-pyrrole

Participants

Reaction Steps

7.0 g of 2-(o-hydroxyphenyl)-pyrrole, 7.3 g of epibromohydrin and 11.4 g of dry potassium carbonate in 50 ml of acetone are refluxed for 7 hours. After the mixture has cooled, it is filtered and the filter residue is washed with acetone. The combined filtrates are freed from the solvent by distillation. The residue is chromatographed twice on silica gel, using methylene chloride as the eluant, and gives 4.6 g (48% of theory) of 2-[2-(2,3-epoxypropoxy)-phenyl]-pyrrole as a colorless oil.

Provenance & Evidence