Sodium Carbonate → 1-(2-Methylthiobenzoyl)-2-cyanoaziridine

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Reaction Steps

1.86 g. 2-Methylthiobenzoyl chloride is dissolved in 14 ml. anhydrous diethyl ether and this solution is added dropwise at ambient temperature to a solution of 0.68 g. 2-cyanoaziridine in 8.6 ml. aqueous 2 N sodium carbonate solution and then stirred for 2 hours, whereafter the ethereal phase is separated off and evaporated to give 1.72 g. of residue which is triturated with 4 ml. isopropanol. There is thus obtained 1.35 g. 1-(2-methylthiobenzoyl)-2-cyanoaziridine; m.p. 67°-69° C.

Provenance & Evidence