Dicyclohexylcarbodiimide → HCID 23461517, compound

Participants

Reaction Steps

5.85 g. N-Acetylglycine, 3.4 g. 2-cyanoaziridine and 10.8 g. dicyclohexylcarbodiimide are stirred in 60 ml. tetrahydrofuran for 2 hours at ambient temperature. The precipitated dicyclohexylurea is filtered off, the filtrate is evaporated and the residue is stirred with diethyl ether, 5.2 g. of crude product thus being obtained. This water-soluble product is recrystallized from methanolic diethyl ether to give 1-(N-acetylglycyl)-2-cyanoaziridine, which melts at 102°-104° C.

Provenance & Evidence