Acetic Anhydride → HCID 15572309, compound

HRID 2286591Notes

Reaction equation

HRID 2286591 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([S:20][C:21]([F:24])([F:23])[F:22])[NH:11][C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)=[CH:4][CH:3]=1.[C:25](OC(=O)C)(=[O:27])[CH3:26]>>[C:25]([N:11]1[C:12]([C:13]2[CH:14]=[CH:15][C:16]([F:19])=[CH:17][CH:18]=2)=[C:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[CH:9]=[C:10]1[S:20][C:21]([F:23])([F:22])[F:24])(=[O:27])[CH3:26]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 15572247HCID 15572247, compound

Product 1

HCID 15572309HCID 15572309, compound

Procedure

A mixture of 1.8 g. of 4,5-bis(4-fluorophenyl)-2-(trifluoromethylthio)pyrrole and 25 ml. of acetic anhydride was heated at reflux with stirring under nitrogen for 2 days and then concentrated under vacuum. The residue was purified by chromatography on Silic AR CC-7 (eluting with hexane and then hexane/toluene) to give 400 mg. of a colorless solid product. Recrystallization from ethanol/H2O gave an analytical sample, m.p. 75°-76° C.

Workup

  1. additionA mixture of 1.8 g
  2. temperatureat reflux
  3. concentrationconcentrated under vacuum
  4. customThe residue was purified by chromatography on Silic AR CC-7 (
  5. washeluting with hexane
  6. customhexane/toluene) to give 400 mg
  7. customRecrystallization from ethanol/H2O
  8. customgave an analytical sample, m.p. 75°-76° C.

Sources & evidence

ORD record
ord-bcced4d15ade4c4794a0a765e62c4897
Source dataset
uspto-grants-1981_05
Patent number
US04267184

Reaction notes

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