Pyridine → HCID 178460290, compound

Participants

Reaction Steps

A suspension of 1.90 g (6.3 mmol) of the above pyrimidine acid and 20 ml of pyridine is stirred at room temperature and 5 ml of propionic anhydride is added. After stirring 1 hr at room temperature, methanol (10 ml) is added and the mixture evaporated to a syrup in vacuo. Water is added to the residue, the pH is adjusted to 2.3 with dilute HCl, and the product filtered. After washing with water and drying gives 1.93 g of 2-[4-(N-propionyl-L-alanylamino)phenyl]-4-hydroxy-5-pyrimidine carboxylic acid; mp 247°-248° C. [α]D25 -81° (cl, pH 7).

Provenance & Evidence