1,1'-Carbonyldiimidazole → HCID 178473774, compound

Participants

Reaction Steps

A mixture of 7.4 g (20 mmol) of (2-[4-(N-acetyl-DL-prolylamino)phenyl]-4-hydroxy-5-pyrimidine carboxylic acid and 6.48 g (40 mmol) of carbonyldiimidazole in 75 ml of tetrahydrofuran is stirred at 51°-52° C. for 1 hr and at room temperature overnight. The reaction mixture is filtered and the solid washed with tetrahydrofuran and ether giving 5.8 grams of the title imidazolide.

Provenance & Evidence