Dimethylformamide → HCID 178516173, compound

Participants

Reaction Steps

A mixture of 13.3 g (38.85 mmol) of the above pyrimidine acid, 12.59 g (77.7 mmol) of carbonyldiimidazole and 100 ml of dimethylformamide is stirred at 54°-59° C. for 1/2 hr and at room temperature for 16 hrs. Acetonitrile (100 ml) and ether (100 ml) are added to the reaction solution. The precipitated solid is filtered, washed with ether, and dried to yield 7.7 g of the title imidazolide.

Provenance & Evidence