Sodium borohydride → HCID 12875598, compound

Participants

Reaction Steps

A mixture of 5.55 parts of 1-(diphenylmethyl)-N-[(6-methyl-2-pyridyl)methylene]-4-piperidinamine, 1.9 part of sodium borohydride and 250 parts by volume of ethanol is stirred at room temperature for about two hours. The reaction mixture is evaporated to dryness in vacuo, the residue partitioned between 200 parts by volume of water and 150 parts by volume of methylene chloride and the layers separated. The aqueous layer is extracted with additional 125 parts by volume of methylene chloride. The methylene chloride fractions are combined, washed with 200 parts by volume of water, dried over anhydrous sodium sulfate, filtered and evaporated to dryness in vacuo to yield, as a yellow oil, 1-(diphenylmethyl)-N-[(6-methyl-2-pyridyl)methyl]-4-piperidinamine. This compound has the following formula ##STR35##

Provenance & Evidence