Sodium borohydride → HCID 12875605, compound

Participants

Reaction Steps

A suspension of 3.55 parts of 1-(diphenylmethyl)-N-[(4-pyridyl)methylene]-4-piperidinamine in 150 parts by volume of ethanol, stirred at room temperature, is treated with 1 part of sodium borohydride. The resultant reaction mixture is stirred at room temperature for about three hours, then evaporated to dryness in vacuo. The residue is partitioned between 100 parts by volume of water and 100 parts by volume of chloroform and the layers separated. The aqueous layer is extracted with additional 100 parts by volume of chloroform and the chloroform layers combined. The combined chloroform fraction is washed with 150 parts by volume of water, dried over anhydrous sodium sulfate and evaporated to dryness to yield 1-(diphenylmethyl)-N-[(4-pyridyl)methyl]-4-piperidinamine which melts, after recrystallization from n-hexane, at about 138°-162° C. This compound is represented by the following structural formula. ##STR37##

Provenance & Evidence