Maleic Acid → HCID 12875611, compound

HRID 2286689Notes

Reaction equation

HRID 2286689 reaction equation
[C:1]1([CH:7]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[N:8]2[CH2:13][CH2:12][CH:11]([NH:14][CH2:15][C:16]3[CH:21]=[CH:20][C:19]4[O:22][CH2:23][O:24][C:18]=4[CH:17]=3)[CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:31]([OH:38])(=[O:37])/[CH:32]=[CH:33]\[C:34]([OH:36])=[O:35]>C(OCC)C>[C:31]([OH:38])(=[O:37])/[CH:32]=[CH:33]\[C:34]([OH:36])=[O:35].[C:25]1([CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[N:8]2[CH2:13][CH2:12][CH:11]([NH:14][CH2:15][C:16]3[CH:21]=[CH:20][C:19]4[O:22][CH2:23][O:24][C:18]=4[CH:17]=3)[CH2:10][CH2:9]2)[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

4

Reactant 2

HCID 444266Maleic AcidHCID 12875610HCID 12875610, compound

Product 1

HCID 12875611HCID 12875611, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

4.85 Parts of 1-(diphenylmethyl)-N-[3,4-(methylenedioxy)benzyl]-4-piperidinamine is dissolved in 150 parts by volume of anhydrous ethyl ether and to this solution is added a solution of 1.5 part of maleic acid in 150 parts by volume of ethyl ether. The resultant mixture is filtered, and the solid washed several times with ethyl ether. The solid is recrystallized from acetonitrile to yield, as colorless needles, 1-(diphenylmethyl)-N-[3,4-(methylenedioxy)benzyl]-4-piperidinamine maleate melting at about 190°-198° C. This compound has the following structural formula. ##STR39##

Workup

  1. filtrationThe resultant mixture is filtered
  2. washthe solid washed several times with ethyl ether
  3. customThe solid is recrystallized from acetonitrile

Sources & evidence

ORD record
ord-8439de5f8dc14a2aa105e979e8de3f17
Source dataset
uspto-grants-1981_05
Patent number
US04267318

Reaction notes

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