HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 2-(trifluoromethyl)quinoline-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Isatin | HCID 7054 | — |
| Reactant | Methyl trifluoromethyl ketone | HCID 9871 | — |
| Reactant | 2-methylquinoline-4-carboxylic acid | HCID 604442 | — |
| Solvent | Potassium Hydroxide | HCID 14797 | — |
| Product | 2-(trifluoromethyl)quinoline-4-carboxylic acid | HCID 9547712 | — |
Reaction Steps
2-Methylcinchoninic acid has been prepared, as disclosed in Bull. Soc. Chem., France, 1956, 1294, by the reaction of isatin and acetone in 30 percent aqueous potassium hydroxide solution. However, it has been found that when isatin is reacted with 1,1,1-trifluoroacetone in an attempt to produce 2-trifluoromethyl cinchoninic acid in an analogous manner, the desired product cannot be obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04267333 |
| Source dataset | uspto-grants-1981_05 |
| ORD ID | ord-8ef972ca10ed432091e55ba22f676b1a |
| Source note | uspto-grants-1981_05 |