Water → HCID 13060090, compound

Participants

Reaction Steps

100 ml of a 70% solution of NaAlH2 (CH3OCH2CH2O)2 in benzene are dropped at 25° into a suspension of 25 g of 3-methyl-6-carbomethoxy-imidazo-(2,1-b)thiazole, prepared as described in Example 8, in 250 ml of dry THF. The suspension is stirred for 2 hours at room temperature and thereafter 25 ml of water are slowly added. The suspension is then filtered and the filtrate concentrated to yield 21 g of 3-methyl-6-hydroxymethyl-imidazo-(2,1-b)thiazole; m.p. 155°-156° (methyl-ethyl-ketone).

Provenance & Evidence