Morpholine → HCID 13060093, compound

HRID 2286724Notes

Reaction equation

HRID 2286724 reaction equation
[CH3:1][C:2]1[N:3]2[CH:9]=[C:8]([CH2:10]Cl)[N:7]=[C:4]2[S:5][CH:6]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>O>[CH3:1][C:2]1[N:3]2[CH:9]=[C:8]([CH2:10][N:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)[N:7]=[C:4]2[S:5][CH:6]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 13060091HCID 13060091, compound

Product 1

HCID 13060093HCID 13060093, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3.4 g of 3-methyl-6-chloromethyl-imidazo-(2,1-b)thiazole are slowly added into 50 ml of cooled and stirred morpholine. The stirring is continued for 1 hour at room temperature and another hour at 40°-50°. The suspension obtained is filtered and the filtrate is evaporated. The residue obtained is dissolved in water and the aqueous solution obtained is extracted with chloroform. The chloroform solution is washed at pH 5-6 with water and after drying it is evaporated. Ethyl acetate is added to the residue to yield 4.5 g of 3-methyl-6-morpholinomethyl-imidazo-(2,1-b)thiazole; m.p. 203°-204° (methyl-ethyl-ketone).

Workup

  1. temperatureof cooled
  2. customThe suspension obtained
  3. filtrationis filtered
  4. customthe filtrate is evaporated
  5. customThe residue obtained
  6. customthe aqueous solution obtained
  7. extractionis extracted with chloroform
  8. washThe chloroform solution is washed at pH 5-6 with water
  9. customafter drying it
  10. customis evaporated
  11. additionEthyl acetate is added to the residue

Sources & evidence

ORD record
ord-c5aca4f8154c4fb0924bf0479370d1fa
Source dataset
uspto-grants-1981_05
Patent number
US04267339

Reaction notes

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