HCID 13060107, compound → HCID 13060126, compound

HRID 2286727Notes

Reaction equation

HRID 2286727 reaction equation
[CH2:1]([C:3]1[S:7][C:6]2=[N:8][C:9]([C:11]([O:13]C)=[O:12])=[CH:10][N:5]2[C:4]=1[CH3:15])[CH3:2]>[OH-].[Na+]>[CH2:1]([C:3]1[S:7][C:6]2=[N:8][C:9]([C:11]([OH:13])=[O:12])=[CH:10][N:5]2[C:4]=1[CH3:15])[CH3:2]

Participants

3

Reactant 1

HCID 13060107HCID 13060107, compound

Product 1

HCID 13060126HCID 13060126, compoundYield 85.3%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

1.5 g of 2-ethyl-3-methyl-6-carbomethoxy-imidazo-(2,1-b)thiazole(obtained as described in Example 45) are refluxed for 2 hours in 5 ml of 10% NaOH. The solution obtained is treated in the same manner as described in Example 49 to yield 1.2 g of 2-ethyl-3-methyl-imidazo-(2,1-b)thiazole-6-carboxylic acid m.p. 243°-245° C.

Workup

  1. customThe solution obtained
  2. additionis treated in the same manner

Sources & evidence

ORD record
ord-a623ba4f77794089bfb776c9df1da61a
Source dataset
uspto-grants-1981_05
Patent number
US04267339

Reaction notes

Loading…