Sulfuric Acid → 1-Methyl-4-nitro-1H-imidazole-2-carbaldehyde

Participants

Reaction Steps

21 parts of 2-dichloromethyl-1-methyl-4-nitroimidazole in 80 parts by volume of 10 percent strength by weight sulfuric acid are stirred for 2 hours at 100° C. The solution is cooled, poured onto ice and neutralized with 55 parts of 6 N sodium hydroxide solution. The aqueous phase is extracted with 4 times 50 parts by volume of methylene chloride. The combined extracts are dried and evaporated. 13 parts of 2-formyl-1-methyl-4-nitroimidazole (83% of theory) of melting point 129° C. are obtained.

Provenance & Evidence