HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl isothiocyanate → Metiamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl isothiocyanate | HCID 11167 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-(((5-Methyl-1H-imidazol-4-yl)methyl)thio)ethylamine dihydrochloride | HCID 3015999 | — |
| Solvent | Water | HCID 962 | — |
| Product | Metiamide | HCID 1548992 | — |
Reaction Steps
Potassium carbonate (7.75 g.) was added to a solution of 14.6 g. of 4-(2-aminoethyl)thiomethyl-5-methylimidazole dihydrochloride in 120 ml. of water. The solution was maintained at ambient temperature for 15 minutes and 5.15 g. of methyl isothiocyanate was added. After heating under reflux for 0.5 hour, the solution was slowly cooled to 5°. The product was collected and recrystallized from water to give N-methyl-N'-[2-(5-methyl-4-imidazolylmethylthio)ethyl]thiourea, m.p. 150°-152°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04267337 |
| Source dataset | uspto-grants-1981_05 |
| ORD ID | ord-cd38c8d960b842f1b34b5e8044adda2a |
| Source note | uspto-grants-1981_05 |