Dimethylformamide → HCID 54556949, compound

Participants

Reaction Steps

To a mixture of 2-isopropyl-4-phenyl-3-butenoic acid (0.22 g, 1.07 mmol), 2 ml DMF, 3 ml THF and potassium carbonate (0.23 g, 1.66 mmol) is added m-phenylcarbonylbenzyl bromide (0.33 g, 1.2 mmol). The reaction mixture is stirred overnight at RT and then ether/water is added. The ether phase is washed with 5% NaOH, water and brine, dried over sodium sulfate and concentrated under vacuum. The crude product is plated on silica gel plates eluting with 10% ether/hexane to yield m-phenylcarbonylbenzyl 2-isopropyl-4-phenyl-3-butenoate, MS m/e 398.3 (M+).

Provenance & Evidence