Sulfuric Acid → HCID 15914246, compound

HRID 2286808Notes

Reaction equation

HRID 2286808 reaction equation
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][CH:23]=1)[C:6](=[O:20])[CH2:7][NH:8][C:9](=O)[C:10]1[C:11](=[CH:15][CH:16]=[CH:17][CH:18]=1)[C:12]([OH:14])=[O:13].S(=O)(=O)(O)O>>[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([C:6]2[O:20][C:9]([C:10]3[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=3[C:12]([OH:14])=[O:13])=[N:8][CH:7]=2)[CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 15914245HCID 15914245, compound

Product 1

HCID 15914246HCID 15914246, compoundYield 91.1%

Procedure

N-(3-trifluoromethylphenacyl) phthalamic acid (9.4 g, 0.027 mol) was added portionwise to conc. sulfuric acid (30 ml) at <10° C. The resultant solution was stirred for 20 hours at room temperature and poured into 600 ml of ice-water to yield 8.2 g of crude 2-[5-(3-trifluoromethylphenyl)-1,3-oxazol-2-yl]benzoic acid as a brown solid; ir (CHCl3) 1720 cm-1. The crude acid was used for subsequent synthesis as obtained.

Sources & evidence

ORD record
ord-05e5bcf7fed041eaaf910f783d05083f
Source dataset
uspto-grants-1981_05
Patent number
US04268299

Reaction notes

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