HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-Chloro-2,3-dihydro-1,4-benzothiazine-3-thione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Phosphorus sulfide (P2S5) | HCID 14817 | — |
| Reactant | 5-chloro-2H-benzo[b][1,4]thiazin-3(4H)-one | HCID 12899263 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 5-Chloro-2,3-dihydro-1,4-benzothiazine-3-thione | HCID 12899281 | 195.8% |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
5-Chloro-2,3-dihydro-1,4-benzothiazine-3-one (2.0 g) and phosphorus pentasulfide (2.0 g) were added to pyridine (5 ml), followed by stirring at 120° C. for 20 minutes. The reaction mixture was then poured into a dilute hydrochloric acid (50 ml), and the precipitated crystals were filtered, washed with water, dried and recrystallized from ethanol to obtain 1.9 g of the objective 5-chloro-2,3-dihydro-1,4-benzothiazine-3-thione (m.p. 138°-140° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04268301 |
| Source dataset | uspto-grants-1981_05 |
| ORD ID | ord-1fe7c3d0f29249c4ab2542e58de61a37 |
| Source note | uspto-grants-1981_05 |