Carbon Dioxide → HCID 674714, compound
Reaction equation
[C:1]12[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=1)[NH:6]C(=O)[O:4][C:2]2=O.[NH2:13][N:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1.C(=O)=O>C(O)C>[NH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:1]=1[C:2]([NH:13][N:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1)=[O:4]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 70 °C
Procedure
33 g isatoic anhydride are suspended in 200 cc ethanol heated to 70° C.; 20.5 g 4-amino-morpholine are slowly added thereto. After completion of the addition, the temperature is maintained at the same level until carbon dioxide is no longer evolved. The ethanol is partly removed (100 cc) and the reaction product is crystallized by addition of 100 cc benzene. It may be purified by recrystallization from a benzene-ethanol mixture. M.P.=172° C.
Workup
- additionAfter completion of the addition
- customThe ethanol is partly removed (100 cc)
- customthe reaction product is crystallized by addition of 100 cc benzene
- customIt may be purified by recrystallization from a benzene-ethanol mixture
Sources & evidence
- ORD record
- ord-10a3d6b1c9054cfc80a1677b85155ca1
- Source dataset
- uspto-grants-1981_05
- Patent number
- US04268511
Reaction notes
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