Acetic Anhydride → HCID 13400252, compound

HRID 2286843Notes

Reaction equation

HRID 2286843 reaction equation
[C:1]([NH:4][N:5]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][C:6]1=[O:16])(=[O:3])[CH3:2].[C:17](OC(=O)C)(=[O:19])[CH3:18]>>[C:1]([N:4]([C:17](=[O:19])[CH3:18])[N:5]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][C:6]1=[O:16])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 892277HCID 892277, compound

Product 1

HCID 13400252HCID 13400252, compound

Procedure

4 g 3-N-acetylamino(1H,3H)quinazoline-2,4-dione are refluxed for 5 hours in 200 cc acetic anhydride. Excess acetic anhydride is then distilled off under reduced pressure. The resulting residue is crystallized from benzene. M.p.=210° C.

Workup

  1. distillationExcess acetic anhydride is then distilled off under reduced pressure
  2. customThe resulting residue is crystallized from benzene

Sources & evidence

ORD record
ord-00ed3bb4b9954e9b9f57d359a877c8b7
Source dataset
uspto-grants-1981_05
Patent number
US04268511

Reaction notes

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