反应详情

Anthranilamide hydrochloride (63.5 g.) was heated under reflux with anhydrous chloral (650 ml.) for three hours. The resulting solution was evaporated to dryness, and the residue was triturated with toluene (700 ml.) to give a yellow product containing one mole of chloral. This was removed by boiling the product with methanol (2 l.) for 15 minutes, cooling the solution and filtering. The filtrate was concentrated to half its volume, and allowed to cool, to produce 1,2-dihydro-2-trichloromethylquinazolin-4-one, m.p. 201°-202° C.

1. customThe resulting solution was evaporated to dryness
2. customthe residue was triturated with toluene (700 ml.)
3. customto give a yellow product
4. customThis was removed
5. customfor 15 minutes
6. temperaturecooling the solution
7. filtrationfiltering
8. concentrationThe filtrate was concentrated to half its volume
9. temperatureto cool