(5-Methoxy-2-nitrophenyl)methanol → (2-Amino-5-methoxyphenyl)methanol

HRID 2286859Notes

Reaction equation

HRID 2286859 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N+:11]([O-])=O)=[C:7]([CH:10]=1)[CH2:8][OH:9].[H][H]>C(O)C.[Pt]=O>[NH2:11][C:6]1[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:10][C:7]=1[CH2:8][OH:9]

Participants

5

Reactant 2

HCID 53405061(5-Methoxy-2-nitrophenyl)methanolHCID 178418361HCID 178418361, compound

Product 1

HCID 13756678(2-Amino-5-methoxyphenyl)methanol

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

This alcohol (2.1 g.) was dissolved in ethanol (100 ml.), Adams' platinum oxide catalyst was added, and the mixture was shaken with hydrogen at ambient temperature and pressure until 950 ml. of hydrogen had been absorbed (theoretical quantity=900 ml.). The hydrogenated mixture was filtered through "Supercel" (trademark) kicselguhr, and the solvent was evaporated to give 2-amino-5-methoxybenzyl alcohol as a brown solid;

Workup

  1. customof hydrogen had been absorbed (theoretical quantity=900 ml.)
  2. filtrationThe hydrogenated mixture was filtered through "Supercel" (trademark) kicselguhr
  3. customthe solvent was evaporated

Sources & evidence

ORD record
ord-90d8477de14145c88145f2d8d884fae7
Source dataset
uspto-grants-1981_05
Patent number
US04268510

Reaction notes

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