Chloral → HCID 13341953, compound

Participants

Reaction Steps

Methyl 4-amino-3-hydroxymethylbenzoate (1 g.) and anhydrous chloral (1 ml.) were mixed together, initially with external ice-cooling, and then on a steam bath for 5 minutes. The product was dissolved in ethyl acetate (100 ml.) and the solution was washed with water (50 ml.), then dried. The solvent was evaporated, and the residue was crystallized from a mixture of ethyl acetate and petroleum ether (b.p. 60°-80 C.) to give methyl 1,2-dihydro-2-trichloromethyl-4H-benzo[d]-[1,3]-oxazine-6-carboxylate, m.p. 178°-179° C.

Provenance & Evidence