Chloral → HCID 13341954, compound

Participants

Reaction Steps

5-Acetoxy-2-aminobenzyl alcohol (8.8 g.) was dissolved in dry diethyl ether (150 ml.), anhydrous chloral (9.6 ml.) was added with stirring over 5 minutes, and the mixture was stirred overnight at room temperature. The solvent was evaporated, and the residue crystallised on stirring with a mixture of methanol (50 ml.) and water (25 ml.) to give 6-acetoxy-1,2-dihydro-2-trichloromethyl-4H-benzo[d]-[1,3]-oxazine, m.p. 155°-157° C.

Provenance & Evidence