HCID 70578492, compound → HCID 70576880, compound

HRID 2286892Notes

Reaction equation

HRID 2286892 reaction equation
Cl.C([N:9]1[CH2:14][CH2:13][C:12]2([C:27]3[CH:26]=[CH:25][CH:24]=[C:23]([O:28][CH3:29])[C:22]=3[O:21][C:20]3[C:15]2=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH2:11][CH2:10]1)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:29][O:28][C:23]1[C:22]2[O:21][C:20]3[C:15]([C:12]4([CH2:13][CH2:14][NH:9][CH2:10][CH2:11]4)[C:27]=2[CH:26]=[CH:25][CH:24]=1)=[CH:16][CH:17]=[CH:18][CH:19]=3

Participants

4

Reactant 1

HCID 70578492HCID 70578492, compound

Product 1

HCID 70576880HCID 70576880, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 1'-benzyl-4-methoxyxanthene-9-spiro-4'-piperidine hydrochloride (3.0 g.) in absolute ethanol (100 ml.) is hydrogenated using 5% palladium on carbon catalyst, at 4 atmospheres pressure and 50° C. The catalyst is filtered off and the solvent evaporated to dryness. The residue is crystallised from ethanol-ether to give 4-methoxyxanthene-9-spiro-4'-piperidine, m.p. 214°-216° C.

Workup

  1. customat 4 atmospheres pressure and 50° C
  2. filtrationThe catalyst is filtered off
  3. customthe solvent evaporated to dryness
  4. customThe residue is crystallised from ethanol-ether

Sources & evidence

ORD record
ord-411a01ca737b43b0849a3c7da97b840d
Source dataset
uspto-grants-1981_05
Patent number
US04268514

Reaction notes

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