Methanesulfonic Acid → HCID 57756597, compound

Participants

Reaction Conditions

Reaction Steps

1-[5-Benzyloxy-2-(6,7-dimethoxy-quinolin-4-yloxy)-phenyl]-ethanone (compound 175) (188 mg) was suspended in a mixed solution composed of methanesulfonic acid (0.3 ml) and trifluoroacetic acid (4 ml) to prepare a suspension which was then stirred at 70° C. for 1.5 hr. The solvent was removed by distillation under the reduced pressure, water was added to the residue, and the mixture was neutralized with sodium hydrogencarbonate powder and was then extracted with chloroform. The chloroform layer was then washed with water and saturated brine and was dried over anhydrous magnesium sulfate. The solvent was removed by distillation under the reduced pressure. The residue was purified by column chromatography using acetone-hexane to give the title compound (145 mg, yield 100%).

Provenance & Evidence