HCID 12880033, compound → HCID 12880036, compound

Participants

Reaction Steps

A solution containing 4.0 grams of the 3-[5-[1-(3,4-dichlorophenoxy)ethyl]-1,3,4-thiadiazol-2-yl]-1-methyl-(2,2-dimethoxyethyl)urea (prepared above) in 200 milliliters of water and 2 milliliters of concentrated hydrochloric acid (HCl) was refluxed for 165 minutes, cooled and then extracted with chloroform CHCl3, and phase separated. The organic phase was dried over MgSO4, filtered, and topped in a roto-vac at 70° C. to yield 3.9 grams of a viscous oil. The viscous oil was dissolved in 20 milliliters of diethylether, and the solution crystallized. The crystals were removed by suction filter, and were dried in a vacuum oven at 80° C. to yield 1.9 grams of white crystals of 3-[5-[1-(3,4-dichlorophenoxy)ethyl]-1,3,4-thiadiazol-2-yl]-1-methyl-4-hydroxy-2-imidazolidinone with a (Melting point 135°-138° C.) and

Provenance & Evidence