Diethylamine → HCID 23459463, compound

Participants

Reaction Conditions

Reaction Steps

87 g. of methanesulfonic acid 2-(1-phenyl-2,5-cyclohexadien-1-yl)-ethyl ester are dissolved in 600 ml. of toluene. 95 ml. (about 3 equivalents) of diethylamine are added and then the mixture is heated at 150° C. in a pressure vessel for 16 hours. The workingup is carried out as described in the second part of Example 7. There is obtained crude N,N-diethyl-1-phenyl-2,5-cyclohexadien-1-ethylamine which is dissolved in ether and converted with hydrogen chloride into the hydrochloride. After recrystallization from methylene chloride/ether, there is obtained the hydrochloride having the melting point of 134°-136° C.

Provenance & Evidence