Acetic Anhydride → HCID 23459519, compound

HRID 2287136Notes

Reaction equation

HRID 2287136 reaction equation
Cl.[CH2:2]([C:4]1([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([OH:18])[CH:13]=2)[O:10][CH2:9][CH2:8][N:7]([CH3:11])[CH2:6][CH2:5]1)[CH3:3].[C:19](OC(=O)C)(=[O:21])[CH3:20]>>[C:19]([O:18][C:14]1[CH:13]=[C:12]([C:4]2([CH2:2][CH3:3])[O:10][CH2:9][CH2:8][N:7]([CH3:11])[CH2:6][CH2:5]2)[CH:17]=[CH:16][CH:15]=1)(=[O:21])[CH3:20]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 23459527HCID 23459527, compound

Product 1

HCID 23459519HCID 23459519, compound

Procedure

2.7 g (0.01 mole) of the 7-ethyl-7-(3-hydroxyphenyl)-4-methyl-hexahydro-1,4-oxazepine hydrochloride obtained as described in Example 2 are boiled with 25 ml of acetic anhydride for 3 hours. The excess acetic anhydride is then distilled off under reduced pressure and the residue is recrystallized from an isopropanol/ether mixture.

Workup

  1. distillationThe excess acetic anhydride is then distilled off under reduced pressure
  2. customthe residue is recrystallized from an isopropanol/ether mixture

Sources & evidence

ORD record
ord-2bcd0bb9ec664073b5578eef30f5647f
Source dataset
uspto-grants-1981_05
Patent number
US04269833

Reaction notes

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