Methyl iodide → 4-phenylmethyl4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one

HRID 2287145Notes

Reaction equation

[N:1]1[N:5]2[C:6]3[C:14]4[CH:15]=[N:16][NH:17][C:13]=4[N:12]=[CH:11][C:7]=3[C:8](=[O:10])[NH:9][C:4]2=[N:3][CH:2]=1.C(N1C2N=CC3C(=O)NC4N(N=CN=4)C=3C=2C=N1)C.[CH2:37](I)[C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1.CI>>[C:38]1([CH2:37][N:9]2[C:8](=[O:10])[C:7]3[CH:11]=[N:12][C:13]4[NH:17][N:16]=[CH:15][C:14]=4[C:6]=3[N:5]3[N:1]=[CH:2][N:3]=[C:4]23)[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1

Participants

Reactant 4

HCID 6328Methyl iodide

HCID 12098Benzyl iodide

HCID 1355938528-Ethyl-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]-triazolo[1,5-a]pyrimidin-5(8H)-one

HCID 1355938534H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one

Product 1

HCID 234596134-phenylmethyl4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one

Procedure

By substituting the 4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one of Example 11 for the 8-ethyl -4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]-triazolo[1,5-a]pyrimidin-5(8H)-one and benzyl iodide for the methyl iodide in the procedure of Example 4, 4-phenylmethyl4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one is obtained.

Sources & evidence

ORD record: ord-11719df1870c4defa5e75ef65a5dcb50
Source dataset: uspto-grants-1981_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04269836

Reaction notes

Loading…