反应详情

A mixture of 6.84 g. of 2-chloro-4,6-bis[(1,1,2,2-tetramethylpropyl)amino]-s-triazine and 7.69 g. of N-(p-methoxyphenyl)piperazine (prepared from the commercially available dihydrochloride salt) in 150 ml. of chlorobenzene is refluxed for 5 hours and then cooled. The reaction mixture is washed with two 25 ml. portions of water. The organic layer is dried over anhydrous potassium carbonate and magnesium sulfate and the solvent is stripped with a water pump. The residual amber oil is crystallized by slurrying in isopropanol. Recrystallization from 150 ml. of propanol (using charcoal for decolorization) gives the desired product as a white solid, m.p. 155°-157° C.

1. additionA mixture of 6.84 g
2. temperaturecooled
3. washThe reaction mixture is washed with two 25 ml
4. dry with materialThe organic layer is dried over anhydrous potassium carbonate and magnesium sulfate
5. customThe residual amber oil is crystallized
6. customRecrystallization from 150 ml