Hydrazinecarboxylic acid, ethyl ester → 5-(1,3-Benzoxazol-2-yl)-1,2-dihydro-3H-1,2,4-triazol-3-one

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Reaction Steps

Methyl benzoxazole-2-imidate, 8.0 g. and 5.2 g. of ethyl carbazate in 60 ml. of dioxane was heated at 110° overnight. After evaporation of solvent, the residue was suspended in 45 ml. of Dowtherm A and heated at 220° for 15 minutes. The precipitated product was filtered, washed with CH2Cl2, CH3OH, and dried to give 3.6 g. of solid, mp. >300°.

Provenance & Evidence