Water → HCID 23459796, compound

Participants

Reaction Steps

Methyl 6,7,8,9-tetrahydro-5-methoxy-4,6-dioxo-10-propyl-4H-naphtho[2,3-b]pyran-2-carboxylate (172 mg; 0.5 mmole) in formic acid (5 ml) was heated on a steam bath with ground potassium iodide (800 mg; 4.8 mmole) for 1 hour. The mixture was poured into water and extracted with ethylacetate (3×). The organic fractions were washed with water and dried (sodium sulphate) to yield a brown oil (180 mg) which crystallised on trituration with ethanol. The solid was filtered off and washed with a little ether to give the title compound as a yellow powder (110 mg; 67%) mp 200° (decomposition).

Provenance & Evidence