HCID 23459925, compound → HCID 23459947, compound

HRID 2287224Notes

Reaction equation

HRID 2287224 reaction equation
[CH3:1][C:2]1[N:6]2[CH:7]=[N:8][CH:9]=[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=3)[C:5]2=[N:4][N:3]=1>CO>[CH3:1][C:2]1[N:6]=[C:5]2[N:4]([CH:7]=[N:8][CH:9]=[C:10]2[C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=2)[N:3]=1

Participants

3

Reactant 1

HCID 23459925HCID 23459925, compound

Product 1

HCID 23459947HCID 23459947, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 0.35 g. of 3-methyl-8-[3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-c]pyrimidine in 5 ml. of methanol is allowed to stand at room temperature. The rearrangement is monitored by thin layer chromatography and is substantially complete after 7 days. The precipitated product is collected by filtration to give 0.14 g. of the product of the example, m.p. 114°-116° C.

Workup

  1. customto stand at room temperature
  2. filtrationThe precipitated product is collected by filtration
  3. customto give 0.14 g

Sources & evidence

ORD record
ord-499e21ec76444282931fab14d4a7e25f
Source dataset
uspto-grants-1981_05
Patent number
US04269980

Reaction notes

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