Methanol, 1,1-diethoxy-, 1-acetate → HCID 23459929, compound

HRID 2287225Notes

Reaction equation

HRID 2287225 reaction equation
[NH:1]([C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=2)[N:4]=1)[NH2:2].[C:19](OC(OCC)OCC)(=O)C>>[F:16][C:15]([F:18])([F:17])[C:11]1[CH:10]=[C:9]([C:5]2[N:4]3[CH:19]=[N:2][N:1]=[C:3]3[CH:8]=[CH:7][N:6]=2)[CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 84166Methanol, 1,1-diethoxy-, 1-acetateHCID 14685624HCID 14685624, compound

Product 1

HCID 23459929HCID 23459929, compound

Procedure

The general procedure of Example 1 is repeated: A solution of 0.300 g. of 4-hydrazino-2-[3-(trifluoromethyl)phenyl]pyrimidine and 1 ml. of diethoxymethyl acetate is stirred at room temperature for 24 hours. The mixture is diluted with an excess of petroleum ether and the precipitate which forms is collected after 20-30 minutes to give 0.182 g. of the product of the example; m.p. 145°-146° C. when recrystallized from chloroform/hexane.

Workup

  1. customthe precipitate which forms is collected after 20-30 minutes
  2. customto give 0.182 g
  3. customm.p. 145°-146° C. when recrystallized from chloroform/hexane

Sources & evidence

ORD record
ord-91eee4e9283f4d2180b4fa0b157b60f5
Source dataset
uspto-grants-1981_05
Patent number
US04269980

Reaction notes

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