Chloride → HCID 54264901, compound

Participants

Reaction Steps

A mixture of 1.0 g. of 1-acetyl-2-(2-phenylpyrimidin-4-yl)hydrazine and 10 ml. of phosphorus oxychloride is heated to the reflux temperature, with stirring, for 7 hours. The mixture is cooled to room temperature, melthylene chloride is added and evaporated under reduced pressure to remove excess phosphorus oxychloride. This is repeated, and the residue is taken up in methylene chloride; the organic layer is washed thoroughly with 5% sodium bicarbonate solution, then with water, dried over anhydrous sodium sulfate and evaporated. The residue is a pale yellow solid which is recrystallized from methylene chloride/hexane. The product of the example, m.p. 140°-145°, is thereby obtained.

Provenance & Evidence