HCID 178523201, compound → HCID 23459933, compound

HRID 2287228Notes

Reaction equation

HRID 2287228 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:4]=[C:5]([C:9]([C:14]2[N:18]=[CH:17][NH:16][N:15]=2)=[CH:10][NH:11][CH:12]=O)[CH:6]=[CH:7][CH:8]=1>CO>[F:1][C:2]([F:20])([F:19])[C:3]1[CH:4]=[C:5]([C:9]2[C:14]3[N:15]([N:16]=[CH:17][N:18]=3)[CH:12]=[N:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 1

HCID 178523201HCID 178523201, compound

Product 1

HCID 23459933HCID 23459933, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The amide from the preceeding example, N-[2-(3-trifluoromethyl-phenyl)-2-(1,2,4-triazol-3-yl)ethenyl]formamide, is dissolved in methanol and the mixture is heated to the reflux temperature for about 60 hours. The solvent is evaporated and the residue is crystallized with the aid of petroleum ether and collected; the product is thereby obtained and is identical with that obtained in Example 16.

Workup

  1. temperaturethe mixture is heated to the reflux temperature for about 60 hours
  2. customThe solvent is evaporated
  3. customthe residue is crystallized with the aid of petroleum ether
  4. customcollected
  5. customthe product is thereby obtained
  6. customthat obtained in Example 16

Sources & evidence

ORD record
ord-a40eda8d1e1b45aeb34db150e34f1c85
Source dataset
uspto-grants-1981_05
Patent number
US04269980

Reaction notes

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