2,2-Dimethoxyethylmethylamine → HCID 13021501, compound

Participants

Reaction Steps

Methylaminoacetaldehyde dimethylacetal (4.2 grams, 0.035 mole) was slowly added at ambient temperature to a 30 milliliter benzene solution containing 9.9 grams (0.035 mole) of the 5-[1-(2-chlorophenoxy)ethyl]-1,3,4-thiadiazol-2-yl isocyanate dimer (prepared above). The resulting solution was refluxed for 20 minutes, cooled and topped on a roto-vac at 70° C. to 13.4 grams of an orange oil which partially crystallized upon standing. The entire sample was recrystallized from a minimum amount of ethylacetate/hexane solution. The crystals were filtered off and dried in a vacuum oven at 80° C. to give 10.2 grams of white crystals of 3-[5-(2-chlorophenoxy)ethyl]-1,3,4-thiadiazol-2-yl]-1-methyl-1-1(2,2-dimethoxyethyl)urea. (Melting point 101°-104° C.).

Provenance & Evidence