反应详情

温度

60 °C

1-[2-(6,7-Dimethoxy-quinolin-4-yloxy)-4,5-dimethylphenyl]-1-ethanone (compound 38) (30 mg) was dissolved in ethanol (1 ml) to prepare a solution. (2-Pyridyl)hydrazine (28 mg) was added to the solution, and the mixture was stirred at 60° C. overnight. Ytterbium triflate (1 mg) was added to the reaction solution, and the mixture was stirred at 60° C. for 5 days. The reaction solution was cooled to room temperature, water was then added to the cooled solution, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was then washed with water and was dried over anhydrous sodium sulfate. The solvent was removed by distillation under the reduced pressure. The residue was purified by thin layer chromatography using hexane-acetone to give the title compound (13 mg, yield 39%).

1. customto prepare a solution
2. stirringthe mixture was stirred at 60° C. for 5 days
3. temperatureThe reaction solution was cooled to room temperature
4. extractionthe mixture was extracted with ethyl acetate
5. washThe ethyl acetate layer was then washed with water
6. dry with materialwas dried over anhydrous sodium sulfate
7. customThe solvent was removed by distillation under the reduced pressure
8. customThe residue was purified by thin layer chromatography