Tetrahydrofuran → HCID 18704405, compound

Participants

Reaction Steps

6.82 g (40 mmol) of benzyl chloroformate (Z--Cl) is added in drops to 10 g (35.03 mmol) of the title compound of Example 19a and 8.86 g (87.57 mmol) of triethylamine in 200 ml of tetrahydrofuran at 0° C. It is stirred for 5 hours at 0° C. It is evaporated to the dry state in a vacuum, the residue is taken up in 300 ml of dichloromethane and washed twice with 200 ml of 5% aqueous hydrochloric acid each. The organic phase is dried on magnesium sulfate and evaporated to the dry state. The residue is recrystallized from diisopropyl ether.

Provenance & Evidence