Trifluoroacetic acid → HCID 23433566, compound

Participants

Reaction Steps

To an oven dried 250 mL round bottom flask equipped with a magnetic stir bar and a N2 gas inlet was added VI (805 mg, 2.76 mmol) in dry CH2Cl2 (50 mL). To the stirred solution was added TFA (10 mL) at room temperature and was allowed to react for 1 h. The solution was concentrated, quenched with saturated NaHCO3 solution, extracted with CH2Cl2, the organic layer dried (MgSO4), concentrated, and purified via radial chromatography (4 mm plate) on silica gel using hexanes followed by hexanes/ethyl acetate (20/1) to afford VII as a clear colorless oil (509 mg, 2.66 mmol, 96%). Spectral data matched that previously disclosed for this compound.

Provenance & Evidence