Hydrochloric Acid → HCID 54555404, compound

Participants

Reaction Steps

Sodium (315 mg) was dissolved in 7.7 ml of ethylene glycol and 700 mg of N-[6-chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]-2-(3-methylphenyl)ethenesulfonamide was added thereto with stirring. The reaction mixture was stirred at 90° C. for 30 minutes and poured into a mixture of 1N hydrochloric acid and ice. Crystals separated out therefrom were collected by filtration and the resulting crystals were purified by a silica gel column chromatography (chloroform-methanol=20:1). The resulting amorphous substance was crystallized in ether and collected filtration to give 533 mg of N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]-2-(3-methylphenyl)ethenesulfonamide.

Provenance & Evidence