反应详情

温度

75 °C

4'-Isobutyl-3'-nitro-2-biphenylsulphonyl chloride (0.353 g) was added to a solution of 2-amino-3-methoxy-5-methylpyrazine (0.139 g) in pyridine (10 ml) at 0° C. The solution w?as heated at 75° C. for 18 hours and then volatile material was removed by evaporation. The residue was purified by elution with dichloromethane through a silica gel Mega Bond Elut column and the resulting foam was triturated with ether/hexane (1:1 v/v) to give 4'-isobutyl-N-(3-methoxy-5-methyl-2-pyrazinyl)-3'-nitro-2-biphenylsulphonamide (0.18 g), m.p. 114-115° C.; mass spectrum (+ve CI): 457 (M+H)+.

1. customvolatile material was removed by evaporation
2. customThe residue was purified by elution with dichloromethane through a silica gel Mega Bond Elut column
3. customthe resulting foam was triturated with ether/hexane (1:1 v/v)