Indole-3-Carboxaldehyde → HCID 22645638, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3,5-dichloro-4-fluorobenzotrifluoride (10 g) in dimethylformamide (10 ml) was added 3-formylindole (623 mg) and potassium carbonate (593 mg), the mixture was heated at 90° C. for 1.5 hrs. The reaction was cooled to room temperature and diluted with water (200 ml) and extracted with ether (200 ml). The organic fraction was separated and evaporated to dryness to give the title compound as a pale yellow crystaline material, m.p. 167-169° C.

Provenance & Evidence