Hydrochloric Acid → 5-Hydroxybenzo[b]thiophene-3-carboxylic acid

Participants

Reaction Steps

A solution of 100 mg (0.3 mmol) of the above obtained 5-benzenesulfonyloxybenzo[b]thiophene-3-carboxylic acid (2) in 1.2 ml of 1N sodium hydroxide was allowed to stand for 8 hours at 40° C. Hydrochloric acid (1N, 1.2 ml) was added thereto, and the precipitated crystals were filtered, washed with water, and dried to give 58 mg of 5-hydroxybenzo[b]thiophene-3-carboxylic acid (1). Yield 96.6% mp 262-263° C.

Provenance & Evidence