HCID 18705088, compound → HCID 18705094, compound

Participants

Reaction Steps

To 1.0 g (3.87 mmol) of 4H-6,8-di-t-butyl-benzopyran-4-one in 8 mL of EtOAc was added 200 mg of 10% Pd/C. The mixture was degassed, followed by addition of H2 gas and stirred under an H2 gas atmosphere for 2 h at RT. After filtration (celite), the product was concentrated and purified (SiO2 chromatography, 5% EtOAc-hexanes) to give 857 mg (3.29 mmol) of 32 as a white solid (85% yield): TLC (5% EtOAc-hex) Rf 0.7; 1H-NMR (CDCl3)δ 1.32 (s, 9H, CH3), 1.42 (s, 9H, CH3), 2.78 (t, J=6.0 Hz, 2H, CH2), 4.52 (t, J=6.0 Hz, 2H, CH2), 7.53 (d, J=2.4 Hz, 1H, Ar--H), 7.81 (d, J=2.4 Hz, 1H, Ar--H)

Provenance & Evidence