Chloroform → HCID 54392061, compound

Participants

Reaction Steps

To a stirred solution of 2,6-dichloro-1-hydroxymethyl-3-[N-methyl-N-[4-(dimethylcarbamoyl)cinnamoylglycyl]amino]benzene (300 mg) and triethylamine (78.5 mg) in dichloromethane (3 ml) was dropwise added mesyl chloride (81.4 mg) under ice-cooling, and the mixture was stirred for 10 minutes at the same temperature and for 30 minutes at ambient temperature. Chloroform was added thereto, and the mixture was washed with saturated sodium bicarbonate solution, water and brine, dried over magnesium sulfate and evaporated in vacuo to give 2,6-dichloro-1-methanesulfonyloxymethyl-3-[N-methyl-N-[4-(dimethylcarbamoyl)cinnamoylglycyl]amino]benzene (330 mg) as colorless amorphous.

Provenance & Evidence