p-Toluenesulfonic acid → HCID 85040011, compound

Participants

Reaction Steps

A solution of 4-ethoxybenzaldehyde (6.62 g, 44.1 mmol) in 200 mL of benzene was refluxed with N-cyclohexylhydroxylamine (6.61 g, 57.4 mmol) in the presence of p-toluenesulfonic acid (0.8 g, 4 mmol) for 72 h. After rotary evaporation, the residue was purified by recrystallization from hexanes and ethylene glycol dimethyl ether (100 mL, 3: 1, v:v) to give the title compound (9.2 g, 84% yield) as a solid, m.p. 124.0° C.

Provenance & Evidence